BABIES BORN WITH DIABETES CAN BE CURED WITHOUT INSULIN | How To Treat Neonatal Diabetes

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How does diabetes affect unborn baby?
What are the risks of being diabetic and pregnant?
What are the chances of having a diabetic child?
Can diabetes cause birth defects?

Infants of mothers who have diabetes may have more difficulty regulating their blood sugar. High blood sugar can be caused by illness or stress. It’s also common in preemies born very early, because the organ that makes insulin (pancreas) is not fully developed

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Babies Born With Diabetes Can Be Cured Without Insulin
Neonatal diabetes mellitus (NDM) is defined as a disease that affects an infant and their body’s ability to produce or use insulin. NDM is a monogenic form of diabetes that occurs in the first 6 months of life. Infants do not produce enough insulin, leading to an increase in glucose accumulation.
PNDM and TNDM are inherited genetically from the mother or father of the infant. Different genetic inheritance or genetic mutations can lead to different diagnosis of NDM, Permanent or Transient Neonatal Diabetes Mellitus.

A new study suggests, Babies born with diabetes can now be treated successfully with tablets instead of injections.
Scientists have examined data collected over the last decade from patients diagnosed with neonatal diabetes who switched from receiving insulin injections to “sulphonylurea tablets”.

Researchers from the University of Exeter have collaborated with groups in Norway, Italy, France and Poland to analyse findings from 81 patients from 20 different countries. The results showed they were successfully treated through sulphonylurea tablets and had excellent blood sugar control over the long-term.

Neonatal diabetes is diagnosed before the age of six months and in half of all cases is caused by a mutation in their KCNJ11 gene, which is involved in keeping insulin-producing cells in the pancreas working properly. This results in life-threatening diabetes soon after birth.

In 2006, scientists discovered that around half of people with neonatal diabetes could “come off insulin” injections and be treated more effectively with “sulphonylurea tablets”. In these patients, the tablets provide the key to unlocking the closed door of the insulin-producing beta cells.

Half of people with type 2 diabetes treated with sulphonylureas no longer have good blood sugar control after five years. Study has found that in neonatal diabetes, the tablets are safe and they work long term – with 93% of people in the study remaining on sulphonylureas alone after 10 years, with excellent blood sugar control

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